The wreck occurred on Rt. 26 near Crum Rd.
Two people were taken to area hospitals following a collision Thursday afternoon along Route 26 at Crum Road.
State Police in Frederick say the operator of an Isuzu box truck failed to yield the right of way to a Volvo tractor trailer whose driver was making a left hand turn.
The operator of the box truck was medivaced to University of Maryland Shock Trauma in Baltimore, and the operator of the tractor trailer was transported to Frederick Memorial Hospital. Medics on the scene say both have non-life threatening injuries.
Route 26 near Crum Road was closed for about a half-hour while State Police conducted their investigation.
State Troopers worked with the State Highway Administration and fire police to re-route traffic around the accident scene.