State Police believe alcohol was a factor.
One person was flown to Shock Trauma in Baltimore on Saturday night following a one-vehicle crash on Interstate 70 east of Frederick.
State Police say a Mercury Station Wagon left westbound I-70 near Route 144, and entered the median. The vehicle struck a guardrail and became disabled. The driver was the sole occupant of the vehicle.
Troopers believe alcohol was a factor in this crash.
Westbound I-70 was closed for about 23-minutes after the accident.
The investigation is continuing.