State Police say the crash involved a motorcycle.
Northbound Route 15 near Monocacy Boulevard is closed at this time following a fatal, two-vehicle crash. That's according to the State Highway Administration's CHART website.
State Police in Frederick say one person was killed in the wreck, which involved a motorcycle.
Motorists who normally head in that direction are urged to find another route.
CHART says the crash was reported at around 9:15 AM on Friday.